Mechanism of Template-independent Nucleotide Incorporation Catalyzed by a Template-dependent DNA Polymerase
نویسندگان
چکیده
منابع مشابه
Human DNA polymerase iota utilizes different nucleotide incorporation mechanisms dependent upon the template base.
Human DNA polymerase iota (Poliota) is a member of the Y family of DNA polymerases involved in translesion DNA synthesis. Poliota is highly unusual in that it possesses a high fidelity on template A, but has an unprecedented low fidelity on template T, preferring to misincorporate a G instead of an A. To understand the mechanisms of nucleotide incorporation opposite different template bases by ...
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ژورنال
عنوان ژورنال: Journal of Molecular Biology
سال: 2007
ISSN: 0022-2836
DOI: 10.1016/j.jmb.2006.10.008